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Increased Tertiary Lymphoid Structures are Associated with Exaggerated Lung Tissue Damage in Smokers with Pulmonary Tuberculosis 期刊论文

编号：

11804CFB8F9A8F4894875D88502E7552
作者：

Zhang, Yue#^[1]Li, Liang(李亮)^[2]Sheng, Zikang^[1];Rao, Yafei^[1];Zhu, Xiang^[3];Pang, Yu^[4];Gao, Mengqiu(高孟秋)^[2]Gai, Xiaoyan*^[1]Sun, Yongchang*^[1]
语种：

英文
期刊：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES ISSN：0895-3988 2025 年 38 卷 7 期 (810 - 818) ; JUL
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学科：

结核学科
关键词：

Tuberculosis Pulmonary tertiary lymphoid structures Cigarette smoking
摘要：

Objective Cigarette smoking exacerbates the progression of pulmonary tuberculosis (TB). The role of tertiary lymphoid structures (TLS) in chronic lung diseases has gained attention; however, it remains unclear whether smoking-exacerbated lung damage in TB is associated with TLS. This study aimed to analyze the characteristics of pulmonary TLS in smokers with TB and to explore the possible role of TLS in smoking-related lung injury in TB. Methods Lung tissues from 36 male patients (18 smokers and 18 non-smokers) who underwent surgical resection for pulmonary TB were included in this study. Pathological and immunohistological analyses were conducted to evaluate the quantity of TLS, and chest computed tomography (CT) was used to assess the severity of lung lesions. The correlation between the TLS quantity and TB lesion severity scores was analyzed. The immune cells and chemokines involved in TLS formation were also evaluated and compared between smokers and non-smokers. Results: Smoker patients with TB had significantly higher TLS than non-smokers ( P < 0.001). The TLS quantity in both the lung parenchyma and peribronchial regions correlated with TB lesion severity on chest CT (parenchyma: r = 0.5767; peribronchial: r = 0.7373; both P < 0.001). Immunohistochemical analysis showed increased B cells, T cells, and C-X-C motif chemokine ligand 13 (CXCL13) expression in smoker patients with TB ( P < 0.001). Conclusion Smoker TB patients exhibited increased pulmonary TLS, which was associated with exacerbated lung lesions on chest CT, suggesting that cigarette smoking may exacerbate lung damage by promoting TLS formation.
推荐引用方式
GB/T 7714：

Zhang Yue,Li Liang,Sheng Zikang, et al. Increased Tertiary Lymphoid Structures are Associated with Exaggerated Lung Tissue Damage in Smokers with Pulmonary Tuberculosis [J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2025,38(7):810-818.
APA：

Zhang Yue,Li Liang,Sheng Zikang,Rao Yafei,&Sun Yongchang.(2025).Increased Tertiary Lymphoid Structures are Associated with Exaggerated Lung Tissue Damage in Smokers with Pulmonary Tuberculosis .BIOMEDICAL AND ENVIRONMENTAL SCIENCES,38(7):810-818.
MLA：

Zhang Yue, et al. "Increased Tertiary Lymphoid Structures are Associated with Exaggerated Lung Tissue Damage in Smokers with Pulmonary Tuberculosis" .BIOMEDICAL AND ENVIRONMENTAL SCIENCES 38,7(2025):810-818.
入库时间：

12/9/2025 9:08:50 PM
更新时间：

12/9/2025 9:08:50 PM

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